Purinergic signaling microenvironments: An introduction

Erik M. Schwiebert, J. Gregory Fitz

Research output: Contribution to journalEditorialpeer-review

8 Scopus citations


The common theme of this introductory article and the minireviews that follow in this special issue is the concept of microenvironments within tissues and surrounding cells that would be ideal signaling venues for a biologically active purinergic ligand. Collectively, the editors/authors and the other contributing authors agree that nucleotides and nucleosides would be most potent within a confined system. A talented cadre of purinergics has been solicited to discuss purinergic signaling in his or her favorite microenvironment within a given organ or tissue. We are gratified by the large number of original articles that also have successfully navigated the peer review process and are part of this special issue. These concepts are not simply purinergic, but the idea of maximal potency in a tissue microenvironment and surrounding specialized cells within a tissue pertains to any autacoid or paracrine agonist.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalPurinergic Signalling
Issue number2
StatePublished - Jun 2008


  • ATP
  • Adenosine
  • Nucleosides
  • Nucleotides
  • Signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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