Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo

Akshay Madan, Sandeep K. Ganji, Zhongxu An, Kevin S. Choe, Marco C. Pinho, Robert M. Bachoo, Elizabeth M. Maher, Changho Choi

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Purpose To evaluate the T2 relaxation time of lactate (Lac) in brain tumors and the correlation of the T2 and concentration with tumor grades. Methods Eight pairs of the subecho time sets of point-resolved spectroscopy were selected between 58 and 268 ms, with numerical and phantom analyses, for Lac T2 measurement. In vivo spectra were acquired from 24 subjects with gliomas (13 low grade and 11 high grade) and analyzed with LCModel using numerically-calculated basis spectra. The metabolite T2 relaxation time was obtained from monoexponential fitting of the multi-echo time (TE) signal estimates versus TE. The metabolite concentration was estimated from the zero-TE extrapolation of the T2 fits. Results The Lac T2 was estimated to be approximately 240 ms, without a significant difference between low and high grade tumors. The Lac concentration was estimated to be 4.1±3.4 and 7.0±4.7 mM for low and high grades respectively, but the difference was not significant. Conclusion The Lac T2 was similar among gliomas regardless of their tumor grades. This suggests that the T2 value from this study may be applicable to obtain the T2 relaxation-free estimates of Lac in a subset of brain tumors. Magn Reson Med 73:2094-2099, 2015.

Original languageEnglish (US)
Pages (from-to)2094-2099
Number of pages6
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Jun 1 2015


  • 3T
  • H MRS
  • PRESS (point-resolved spectroscopy)
  • T
  • brain tumors
  • glioma
  • lactate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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