Proton spectroscopy in asymptomatic HIV-infected adults: Initial results in a prospective cohort study

Jeffrey G. Jarvik, Robert E. Lenkinski, Andrew J. Saykin, Anna Jaans, Ian Frank

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The purpose of our study was to determine whether proton magnetic resonance spectroscopy (MRS) could detect early brain involvement by human immunodeficiency virus (HIV). We recruited 19 asymptomatic HIV-infected patients, 9 with and 10 without a history of intravenous drug use (IDU), as well as 10 control subjects. All subjects had to have normal MR imaging to be enrolled. We identified the following peaks on proton MRS: n-acetyl aspartate, creatine, choline, and a conglomerate amino acid peak between 2.1 and 2.6 parts per million that we call the marker peaks. Proton MRS was able to demonstrate a statistically significant difference between HIV-infected subjects and controls. The marker/Cr was the best ratio to separate patients from controls, with controls having a mean ratio of 0.50 ± 0.51 and patients having a mean ratio of 1.8 ± 0.85 (p = 0.001). There was no difference between HIV-infected subjects with and without a history of IDU. No significant relationship was found between either neuropsychological test scores or CD4 count and metabolite ratios. In brief, MRS seems more sensitive than magnetic resonance imaging (MRI), being able to detect abnormalities in HIV-infected patients when imaging is normal.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Issue number3
StatePublished - 1996


  • HIV
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology


Dive into the research topics of 'Proton spectroscopy in asymptomatic HIV-infected adults: Initial results in a prospective cohort study'. Together they form a unique fingerprint.

Cite this