TY - JOUR
T1 - Proton spectral editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivo
AU - Choi, Changho
AU - Coupland, Nicholas J.
AU - Kalra, Sanjay
AU - Bhardwaj, Paramjit P.
AU - Malykhin, Nikolai
AU - Allen, Peter S.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - A single-voxel proton NMR J-difference editing method for discriminating between the 1.31 ppm resonances of lactate (Lac) and threonine (Thr) in human brain in vivo at 3 T is reported. One double-band and two triple-band Gaussian 180° RF pulses, all with a bandwidth of 15 Hz, were employed within an adiabatic-refocused double-echo localization sequence to induce the target signals of Lac and Thr and simultaneously acquire a creatine singlet in each subscan. The optimum echo time and the editing efficiency were obtained by numerical analysis of the filtering performance. The Lac and Thr signals were extracted, without lipid contamination, from three subspectra. Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47 ± 0.07 and 0.55 ± 0.06 mM (mean ± SD, M = 7), respectively, with reference to Cr at 8 mM.
AB - A single-voxel proton NMR J-difference editing method for discriminating between the 1.31 ppm resonances of lactate (Lac) and threonine (Thr) in human brain in vivo at 3 T is reported. One double-band and two triple-band Gaussian 180° RF pulses, all with a bandwidth of 15 Hz, were employed within an adiabatic-refocused double-echo localization sequence to induce the target signals of Lac and Thr and simultaneously acquire a creatine singlet in each subscan. The optimum echo time and the editing efficiency were obtained by numerical analysis of the filtering performance. The Lac and Thr signals were extracted, without lipid contamination, from three subspectra. Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47 ± 0.07 and 0.55 ± 0.06 mM (mean ± SD, M = 7), respectively, with reference to Cr at 8 mM.
KW - Double-band and triple-band 180° RF pulses
KW - Human brain
KW - J-difference editing
KW - Lactate
KW - Threonine
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U2 - 10.1002/mrm.20988
DO - 10.1002/mrm.20988
M3 - Article
C2 - 16892185
AN - SCOPUS:33748376646
SN - 0740-3194
VL - 56
SP - 660
EP - 665
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 3
ER -