Proton magnetic resonance spectroscopy of pediatric brain tumors

L. N. Sutton; Z. Wang; D. Gusnard; B. Lange; G. Perilongo; A. R. Bogdan; J. A. Detre; L. Rorke; R. A. Zimmerman

doi:10.1227/00006123-199208000-00004

Proton magnetic resonance spectroscopy of pediatric brain tumors

L. N. Sutton, Z. Wang, D. Gusnard, B. Lange, G. Perilongo, A. R. Bogdan, J. A. Detre, L. Rorke, R. A. Zimmerman

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

¹H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.

Original language	English (US)
Pages (from-to)	195-202
Number of pages	8
Journal	Neurosurgery
Volume	31
Issue number	2
DOIs	https://doi.org/10.1227/00006123-199208000-00004
State	Published - Aug 1992

Keywords

Astrocytoma
Brain tumor
Glioma
Medulloblastoma
Nuclear magnetic resonance
Spectroscopy

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1227/00006123-199208000-00004

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title = "Proton magnetic resonance spectroscopy of pediatric brain tumors",

abstract = "1H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.",

keywords = "Astrocytoma, Brain tumor, Glioma, Medulloblastoma, Nuclear magnetic resonance, Spectroscopy",

author = "Sutton, {L. N.} and Z. Wang and D. Gusnard and B. Lange and G. Perilongo and Bogdan, {A. R.} and Detre, {J. A.} and L. Rorke and Zimmerman, {R. A.}",

year = "1992",

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doi = "10.1227/00006123-199208000-00004",

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T1 - Proton magnetic resonance spectroscopy of pediatric brain tumors

AU - Sutton, L. N.

AU - Wang, Z.

AU - Gusnard, D.

AU - Lange, B.

AU - Perilongo, G.

AU - Bogdan, A. R.

AU - Detre, J. A.

AU - Rorke, L.

AU - Zimmerman, R. A.

PY - 1992/8

Y1 - 1992/8

N2 - 1H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.

AB - 1H MAGNETIC RESONANCE spectroscopy allows the regional quantitation of a number of metabolites from the brain in a noninvasive fashion. Spectra were obtained from 5 normal children and 25 children with brain tumors. Choline (Cho), acetylaspartate (NAA), creatine and phosphocreatine, and lactate were quantitated in the form of ratios. The brains of normal children showed relatively high concentrations of Cho and NAA and virtually no lactate, as has been shown in adults. Benign astrocytomas and ependymomas were characterized by an elevation of the Cho:NAA ratio and an abnormal accumulation of lactate. Intrinsic malignant tumors were remarkable for an even higher Cho:NAA ratio but had no more lactate than was found in the benign tumors. Proton magnetic resonance spectroscopy may prove useful in characterizing neoplastic tissue in conjunction with more conventional imaging modalities.

KW - Astrocytoma

KW - Brain tumor

KW - Glioma

KW - Medulloblastoma

KW - Nuclear magnetic resonance

KW - Spectroscopy

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AN - SCOPUS:0026768416

SN - 0148-396X

VL - 31

SP - 195

EP - 202

JO - Neurosurgery

JF - Neurosurgery

IS - 2

ER -

Proton magnetic resonance spectroscopy of pediatric brain tumors

Abstract

Keywords

ASJC Scopus subject areas

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