Abstract
CHIP is a ubiquitin ligase implicated in the degradation of misfolded proteins. In the November 23 issue of Molecular Cell, Zhang et al. (2005) identified CHIP as a protein that interacts with the ubiquitin E2 complex Ubc13-Uev1A, which catalyzes the synthesis of Lys-63-linked polyubiquitin chains. Although the ubiquitin ligase activity of CHIP requires its dimerization through the U box domain, the crystal structure of the CHIP-E2 complex reveals that the protomers in the CHIP homodimer adopt distinct conformations such that only one U box of CHIP interacts with Ubc13.
Original language | English (US) |
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Pages (from-to) | 653-655 |
Number of pages | 3 |
Journal | Molecular cell |
Volume | 20 |
Issue number | 5 |
DOIs | |
State | Published - Dec 9 2005 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology