TY - JOUR
T1 - Protein sensors for membrane sterols
AU - Goldstein, Joseph L.
AU - DeBose-Boyd, Russell A.
AU - Brown, Michael S.
N1 - Funding Information:
The authors' research is supported by the NIH (PO1-HL20948 and KO1-HL70441) and the Perot Family Foundation. R.A.D.-B. is the recipient of an Established Investigator Award of the American Heart Association.
PY - 2006/1/13
Y1 - 2006/1/13
N2 - Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
AB - Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
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U2 - 10.1016/j.cell.2005.12.022
DO - 10.1016/j.cell.2005.12.022
M3 - Review article
C2 - 16413480
AN - SCOPUS:30344473341
SN - 0092-8674
VL - 124
SP - 35
EP - 46
JO - Cell
JF - Cell
IS - 1
ER -