Protein quality control and metabolism: Bidirectional control in the heart

Zhao Wang, Joseph A Hill

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms - autophagy, the unfolded protein response, and the ubiquitin-proteasome system - act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.

Original languageEnglish (US)
Pages (from-to)215-226
Number of pages12
JournalCell Metabolism
Issue number2
StatePublished - Feb 3 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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