TY - JOUR
T1 - Protein quality control and metabolism
T2 - Bidirectional control in the heart
AU - Wang, Zhao
AU - Hill, Joseph A
N1 - Funding Information:
This work was supported by grants from the NIH (HL-120732; HL-100401), AHA (14SFRN20740000), CPRIT (RP110486P3), and the Leducq Foundation (11CVD04). Z.V.W. was supported by a Scientist Development Grant from the American Heart Association (14SDG18440002). We declare no conflicts of interest.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/2/3
Y1 - 2015/2/3
N2 - The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms - autophagy, the unfolded protein response, and the ubiquitin-proteasome system - act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.
AB - The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms - autophagy, the unfolded protein response, and the ubiquitin-proteasome system - act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.
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U2 - 10.1016/j.cmet.2015.01.016
DO - 10.1016/j.cmet.2015.01.016
M3 - Review article
C2 - 25651176
AN - SCOPUS:84922946917
SN - 1550-4131
VL - 21
SP - 215
EP - 226
JO - Cell Metabolism
JF - Cell Metabolism
IS - 2
ER -