Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

S. G. Birnbaum; P. X. Yuan; M. Wang; S. Vijayraghavan; A. K. Bloom; D. J. Davis; K. T. Gobeske; J. D. Sweatt; H. K. Manji; A. F T Arnsten

doi:10.1126/science.1100021

Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

S. G. Birnbaum, P. X. Yuan, M. Wang, S. Vijayraghavan, A. K. Bloom, D. J. Davis, K. T. Gobeske, J. D. Sweatt, H. K. Manji, A. F T Arnsten

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.

Original language	English (US)
Pages (from-to)	882-884
Number of pages	3
Journal	Science
Volume	306
Issue number	5697
DOIs	https://doi.org/10.1126/science.1100021
State	Published - Oct 29 2004

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1100021

Cite this

@article{d1a61a74995944c3b0da8f2f7be01f88,

title = "Protein kinase C overactivity impairs prefrontal cortical regulation of working memory",

abstract = "The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.",

author = "Birnbaum, {S. G.} and Yuan, {P. X.} and M. Wang and S. Vijayraghavan and Bloom, {A. K.} and Davis, {D. J.} and Gobeske, {K. T.} and Sweatt, {J. D.} and Manji, {H. K.} and Arnsten, {A. F T}",

year = "2004",

month = oct,

day = "29",

doi = "10.1126/science.1100021",

language = "English (US)",

volume = "306",

pages = "882--884",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5697",

}

TY - JOUR

T1 - Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

AU - Birnbaum, S. G.

AU - Yuan, P. X.

AU - Wang, M.

AU - Vijayraghavan, S.

AU - Bloom, A. K.

AU - Davis, D. J.

AU - Gobeske, K. T.

AU - Sweatt, J. D.

AU - Manji, H. K.

AU - Arnsten, A. F T

PY - 2004/10/29

Y1 - 2004/10/29

N2 - The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.

AB - The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.

UR - http://www.scopus.com/inward/record.url?scp=7444256727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7444256727&partnerID=8YFLogxK

U2 - 10.1126/science.1100021

DO - 10.1126/science.1100021

M3 - Article

C2 - 15514161

AN - SCOPUS:7444256727

SN - 0036-8075

VL - 306

SP - 882

EP - 884

JO - Science

JF - Science

IS - 5697

ER -

Protein kinase C overactivity impairs prefrontal cortical regulation of working memory

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this