Protein kinase C in the postmortem brain of teenage suicide victims

Ghanshyam N. Pandey; Yogesh Dwivedi; Subhash C. Pandey; Robert R. Conley; Rosalinda C. Roberts; Carol A. Tamminga

doi:10.1016/S0304-3940(97)00378-9

Protein kinase C in the postmortem brain of teenage suicide victims

Ghanshyam N. Pandey, Yogesh Dwivedi, Subhash C. Pandey, Robert R. Conley, Rosalinda C. Roberts, Carol A. Tamminga

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Increased serotonin (2A) (5-HT(2A)) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [³H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [³H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B(max) of [³H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Neuroscience letters
Volume	228
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(97)00378-9
State	Published - Jun 6 1997

Keywords

Postmortem brain
Protein kinase C
Teenage suicide

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(97)00378-9

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title = "Protein kinase C in the postmortem brain of teenage suicide victims",

abstract = "Increased serotonin (2A) (5-HT(2A)) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B(max) of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.",

keywords = "Postmortem brain, Protein kinase C, Teenage suicide",

author = "Pandey, {Ghanshyam N.} and Yogesh Dwivedi and Pandey, {Subhash C.} and Conley, {Robert R.} and Roberts, {Rosalinda C.} and Tamminga, {Carol A.}",

note = "Funding Information: This work was supported by a grant from the National Institute of Mental Health (ROIMH 48153-04 and MH 40279). We acknowledge with thanks the cooperation of Dr. John Smailek, Chief Medical Examiner, and Dr. Dennis Chute, Assistant Medical Examiner, in the collection of brain samples, and Ms. Terri U'Prichard for performing the psychological autopsies.",

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doi = "10.1016/S0304-3940(97)00378-9",

language = "English (US)",

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T1 - Protein kinase C in the postmortem brain of teenage suicide victims

AU - Pandey, Ghanshyam N.

AU - Dwivedi, Yogesh

AU - Pandey, Subhash C.

AU - Conley, Robert R.

AU - Roberts, Rosalinda C.

AU - Tamminga, Carol A.

N1 - Funding Information: This work was supported by a grant from the National Institute of Mental Health (ROIMH 48153-04 and MH 40279). We acknowledge with thanks the cooperation of Dr. John Smailek, Chief Medical Examiner, and Dr. Dennis Chute, Assistant Medical Examiner, in the collection of brain samples, and Ms. Terri U'Prichard for performing the psychological autopsies.

PY - 1997/6/6

Y1 - 1997/6/6

N2 - Increased serotonin (2A) (5-HT(2A)) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B(max) of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.

AB - Increased serotonin (2A) (5-HT(2A)) receptors have been reported in the postmortem brain of suicide victims. To examine if this increase is associated with the dysregulation of postreceptor sites in the signaling cascade, we determined [3H]phorbol dibutyrate (PDBU) binding to protein kinase C (PKC) in postmortem brain samples (Brodmann's areas 8 and 9) obtained from teenage suicide victims and control subjects. [3H]PDBU binding to PKC was determined in membranal and cytosolic fractions. We observed that B(max) of [3H]PDBU binding sites was significantly decreased in both membranal and cytosolic fractions in brain samples from Brodmann's areas 8-9 compared to matched controls. These results thus suggest that PKC may play a role in the pathophysiology of suicidal behavior.

KW - Postmortem brain

KW - Protein kinase C

KW - Teenage suicide

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Protein kinase C in the postmortem brain of teenage suicide victims

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