Protein homeostasis and aging in neurodegeneration

Peter M. Douglas, Andrew Dillin

Research output: Contribution to journalReview articlepeer-review

270 Scopus citations


Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of cellular dysfunctions and neuronal death. However, recent findings suggest that the assembly of disease proteins into tightly ordered aggregates can significantly delay proteotoxic onset. Furthermore, manipulation of metabolic pathways through key signaling components extends lifespan, bolsters proteostasis networks, and delays the onset of proteotoxicity. Thus, understanding the relationship between proteostasis and aging has provided important insights into neurodegeneration.

Original languageEnglish (US)
Pages (from-to)719-729
Number of pages11
JournalJournal of Cell Biology
Issue number5
StatePublished - Sep 6 2010

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Protein homeostasis and aging in neurodegeneration'. Together they form a unique fingerprint.

Cite this