TY - JOUR
T1 - Protein degradation and iron homeostasis
AU - Thompson, Joel W.
AU - Bruick, Richard K.
N1 - Funding Information:
R.K.B. is the Michael L. Rosenberg Scholar in Medical Research and is supported by a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund . J.W.T. was supported by the Graduate Programs Initiative from the UT Board of Regents .
PY - 2012/9
Y1 - 2012/9
N2 - Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia Inducible Factor (HIF), and ferroportin. Notably, the stability of each of these proteins is regulated in response to iron. Recent discoveries have greatly advanced our understanding of the molecular mechanisms governing iron-sensing and protein degradation within these pathways. It has become clear that iron's privileged roles in both enzyme catalysis and protein structure contribute to its regulation of protein stability. Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals.
AB - Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia Inducible Factor (HIF), and ferroportin. Notably, the stability of each of these proteins is regulated in response to iron. Recent discoveries have greatly advanced our understanding of the molecular mechanisms governing iron-sensing and protein degradation within these pathways. It has become clear that iron's privileged roles in both enzyme catalysis and protein structure contribute to its regulation of protein stability. Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals.
KW - F-box and Leucine-rich Repeat Protein 5
KW - Ferroportin
KW - Hemerythrin domain
KW - Hypoxia Inducible Factor
KW - Iron Regulatory Proteins
KW - Iron homeostasis
UR - http://www.scopus.com/inward/record.url?scp=84864312739&partnerID=8YFLogxK
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U2 - 10.1016/j.bbamcr.2012.02.003
DO - 10.1016/j.bbamcr.2012.02.003
M3 - Review article
C2 - 22349011
AN - SCOPUS:84864312739
SN - 0167-4889
VL - 1823
SP - 1484
EP - 1490
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 9
ER -