Abstract
Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications. Therefore such acetylation modifications might be coupled to the intracellular availability of acetyl-CoA. In the present article, we summarize recent evidence suggesting that the particular protein acetylation modifications enable the regulation of protein function in tune with acetyl-CoA availability and thus the metabolic state of the cell.
Original language | English (US) |
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Pages (from-to) | 1037-1042 |
Number of pages | 6 |
Journal | Biochemical Society Transactions |
Volume | 42 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2014 |
Keywords
- Acetyl-CoA
- Acetylation
- Epigenetics
- Metabolism
ASJC Scopus subject areas
- Biochemistry