Proteases control many physiological responses, thus the identification and characterization of specific proteases offers the prospect of new medical adbances. Study of the structure-function relationships in protease-catalyzed hydrolysis of the peptide bond has adbanced our understanding of enzyme catalysis and specificity. Three-dimensional structures have been solved for each mechanistic class of protease, and these studies have been extended using site-directed mutagenesis to characterize the amino acid residues required for enzyme function.
|Original language||English (US)|
|Number of pages||8|
|Journal||Current Opinion in Structural Biology|
|State||Published - Oct 1992|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology