Margaret A. Phillips, Robert J. Fletterick

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Proteases control many physiological responses, thus the identification and characterization of specific proteases offers the prospect of new medical adbances. Study of the structure-function relationships in protease-catalyzed hydrolysis of the peptide bond has adbanced our understanding of enzyme catalysis and specificity. Three-dimensional structures have been solved for each mechanistic class of protease, and these studies have been extended using site-directed mutagenesis to characterize the amino acid residues required for enzyme function.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalCurrent Opinion in Structural Biology
Issue number5
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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