Prostate cancer is the leading cancer diagnosed in males. Emerging data suggests that cancer arises from only certain cells, termed cancer stem cells, contained within the prostate. In this chapter we will discuss in depth the prostate cancer stem cell. We detail the properties of both normal prostate stem cells and cancer stem cells and discuss the identification and isolation of the prostate cancer stem cells, including the current knowledge of the surface markers used for identification. Furthermore, we discuss the signaling pathways that are important in stem cell maintenance and comment on what is known about these pathways in prostate cancer stem cells and how these pathways, and others, may be targeted to inhibit or kill the tumor-initiating cancer stem cells. In conclusion, we provide a short discussion on the future directions for study of prostate cancer stem cells.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)