Prospective research on infants with mild encephalopathy: The PRIME study

C. Prempunpong; L. F. Chalak; J. Garfinkle; B. Shah; V. Kalra; N. Rollins; R. Boyle; K. A. Nguyen; I. Mir; A. Pappas; P. Montaldo; S. Thayyil; P. J. Sánchez; S. Shankaran; A. R. Laptook; G. Sant'anna

doi:10.1038/jp.2017.164

Prospective research on infants with mild encephalopathy: The PRIME study

C. Prempunpong, L. F. Chalak, J. Garfinkle, B. Shah, V. Kalra, N. Rollins, R. Boyle, K. A. Nguyen, I. Mir, A. Pappas, P. Montaldo, S. Thayyil, P. J. Sánchez, S. Shankaran, A. R. Laptook, G. Sant'anna

Research output: Contribution to journal › Review article › peer-review

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Abstract

Objective:To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.Study Design:Prospective multicenter study. Mild NE was defined as 3/41 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.Results:A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.Conclusions:A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.

Original language	English (US)
Pages (from-to)	80-85
Number of pages	6
Journal	Journal of Perinatology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1038/jp.2017.164
State	Published - Jan 1 2018

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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Prempunpong, C., Chalak, L. F., Garfinkle, J., Shah, B., Kalra, V., Rollins, N., Boyle, R., Nguyen, K. A., Mir, I., Pappas, A., Montaldo, P., Thayyil, S., Sánchez, P. J., Shankaran, S., Laptook, A. R., & Sant'anna, G. (2018). Prospective research on infants with mild encephalopathy: The PRIME study. Journal of Perinatology, 38(1), 80-85. https://doi.org/10.1038/jp.2017.164

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title = "Prospective research on infants with mild encephalopathy: The PRIME study",

abstract = "Objective:To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.Study Design:Prospective multicenter study. Mild NE was defined as 3/41 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.Results:A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.Conclusions:A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.",

author = "C. Prempunpong and Chalak, {L. F.} and J. Garfinkle and B. Shah and V. Kalra and N. Rollins and R. Boyle and Nguyen, {K. A.} and I. Mir and A. Pappas and P. Montaldo and S. Thayyil and S{\'a}nchez, {P. J.} and S. Shankaran and Laptook, {A. R.} and G. Sant'anna",

note = "Funding Information: Funding source: Chatchay Prempunpong was funded by a scholarship for her Neonatal Perinatal Medicine fellowship training from the Department of Pediatrics at McGill University. Dr L Chalak is supported by NIH Grant K23HD069521. Paolo Montaldo and Sudhin Thayyil are supported by grants from the National Institute of Publisher Copyright: {\textcopyright} 2018 Nature America, Inc., part of Springer Nature. All rights reserved.",

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doi = "10.1038/jp.2017.164",

language = "English (US)",

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T1 - Prospective research on infants with mild encephalopathy

T2 - The PRIME study

AU - Prempunpong, C.

AU - Chalak, L. F.

AU - Garfinkle, J.

AU - Shah, B.

AU - Kalra, V.

AU - Rollins, N.

AU - Boyle, R.

AU - Nguyen, K. A.

AU - Mir, I.

AU - Pappas, A.

AU - Montaldo, P.

AU - Thayyil, S.

AU - Sánchez, P. J.

AU - Shankaran, S.

AU - Laptook, A. R.

AU - Sant'anna, G.

N1 - Funding Information: Funding source: Chatchay Prempunpong was funded by a scholarship for her Neonatal Perinatal Medicine fellowship training from the Department of Pediatrics at McGill University. Dr L Chalak is supported by NIH Grant K23HD069521. Paolo Montaldo and Sudhin Thayyil are supported by grants from the National Institute of Publisher Copyright: © 2018 Nature America, Inc., part of Springer Nature. All rights reserved.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective:To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.Study Design:Prospective multicenter study. Mild NE was defined as 3/41 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.Results:A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.Conclusions:A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.

AB - Objective:To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.Study Design:Prospective multicenter study. Mild NE was defined as 3/41 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.Results:A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.Conclusions:A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.

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Prospective research on infants with mild encephalopathy: The PRIME study

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