Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen

A. P. Feranchak, M. K. Sontag, J. S. Wagener, K. B. Hammond, F. J. Accurso, R. J. Sokol

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Objective: To prospectively evaluate the biochemical status of vitamins A, D, and E in children with cystic fibrosis (CF). Subjects: A total of 127 infants identified by the Colorado CF newborn screening program. Design: Vitamin status (serum retinol, 25-hydroxy vitamin D, ratio of alpha- tocopherol/total lipids) and serum albumin were assessed at diagnosis (4 to 8 weeks), ages 6 months, 12 months, and yearly thereafter, to age 10 years. Results: Deficiency of 1 or more vitamins was present in 44 (45.8%) of 96 patients at age 4 to 8 weeks as follows: vitamin A 29.0%, vitamin D 22.5%, and vitamin E 22.8%. Of these patients with initial deficiency, the percent that was deficient at 1 or more subsequent time points, despite supplementation, was vitamin A 11.1%, vitamin D 12.5%, and vitamin E 57.1%. Of the initial patients with vitamin sufficiency, the percent who became deficient at any time during the 10-year period was as follows: vitamin A 4.5%, vitamin D 14.4%, and vitamin E 11.8%. The percent of patients deficient for 1 or more vitamins ranged from 4% to 45% for any given year. Conclusions: Despite supplementation with standard multivitamins and pancreatic enzymes, the sporadic occurrence of fat-soluble vitamin deficiency and persistent deficiency is relatively common. Frequent and serial monitoring of the serum concentrations of these vitamins is therefore essential in children with CF.

Original languageEnglish (US)
Pages (from-to)601-610
Number of pages10
JournalJournal of Pediatrics
Issue number5
StatePublished - 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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