To the Editor: I enjoyed reading the timely article by Drs. Holland and Kaplan (N Engl J Med 294:930–935, 1976). However, I wish to differ with their statement that volume expansion is relatively infrequent. In support of their observations, the authors have cited two excellent studies.12An interesting, but conflicting, paper has been presented by Drayer and his co-workers.3In a beautifully controlled study, they compared the long-term effects of sulfonamide diuretic agents with an aldosterone-blocking drug and then with propranolol, in the same patients. This study relied on measurement of body weight (the one cited by the authors.
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