Prophylactic Antibiotics for Suction Curettage in Incomplete Abortion

Kirk D. Ramin, Susan M. Ramin, Patricia G. Hemsell, Brenda J. Nobles, Molly G. Heard, Vivian B. Johnson, David L. Hemsell

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: The purpose of this study was to investigate the efficacy of 200 mg of prophylactic doxycycline in preventing pelvic infection after curettage for spontaneous (incomplete) abortion. Methods: A randomized, prospective, double-blinded study was carried out involving 300 women with an incomplete abortion who were given either placebo or 200 mg of doxycycline orally 30-60 min prior to curettage. A hematocrit, WBG count, pregnancy test, syphilis serology, Neisseria gonorrhoeae culture, and MicroTrak (monoclonal antibody test, Syba, San Jose, GA) for Chlamydia trachomatis were performed. The patients were scheduled for follow-up 2 weeks later. Antibiotic administration for any reason as well as the postoperative infection rate in these women was assessed. Results: Eleven women were excluded from analysis, leaving 289 evaluable. TV. gonorrhoeae was isolated from 6 (2%) women and C. trachomatis from 8 (3%) women, and the syphilis serology was serofast in 4 (1%) women. Endometritis complicated the procedure in 4 women who received placebo and in 1 woman who received doxycycline (P = 0.22). Conclusion: Prophylactic doxycycline is not effective in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalInfectious Diseases in Obstetrics and Gynecology
Issue number5
StatePublished - 1995


  • Endometritis
  • doxycycline
  • prophylaxis
  • spontaneous abortion

ASJC Scopus subject areas

  • Dermatology
  • Obstetrics and Gynecology
  • Infectious Diseases


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