Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration

John T. Lis, W. Lee Kraus

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations


Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.

Original languageEnglish (US)
Pages (from-to)1225-1227
Number of pages3
Issue number7
StatePublished - Jun 30 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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