Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration

John T. Lis; W. Lee Kraus

doi:10.1016/j.cell.2006.06.016

Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration

John T. Lis, W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

22 Scopus citations

Abstract

Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.

Original language	English (US)
Pages (from-to)	1225-1227
Number of pages	3
Journal	Cell
Volume	125
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2006.06.016
State	Published - Jun 30 2006

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.cell.2006.06.016

Cite this

@article{da38c02e5b124a47b9e793b49ad3c5f2,

title = "Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration",

abstract = "Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.",

author = "Lis, {John T.} and Kraus, {W. Lee}",

year = "2006",

month = jun,

day = "30",

doi = "10.1016/j.cell.2006.06.016",

language = "English (US)",

volume = "125",

pages = "1225--1227",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "7",

}

TY - JOUR

T1 - Promoter Cleavage

T2 - A TopoIIβ and PARP-1 Collaboration

AU - Lis, John T.

AU - Kraus, W. Lee

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.

AB - Hormones trigger dramatic changes in the structure and transcriptional activity of specific promoters that lead to exchange of repression complexes for activation complexes. Ju et al. (2006) now show that estrogen-dependent restructuring and transcription of the pS2 promoter require the generation of a DNA double-strand break by a novel protein complex containing two enzymes, topoisomerase IIβ and poly(ADP-ribose) polymerase.

UR - http://www.scopus.com/inward/record.url?scp=33745278510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745278510&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2006.06.016

DO - 10.1016/j.cell.2006.06.016

M3 - Short survey

C2 - 16814707

AN - SCOPUS:33745278510

SN - 0092-8674

VL - 125

SP - 1225

EP - 1227

JO - Cell

JF - Cell

IS - 7

ER -

Promoter Cleavage: A TopoIIβ and PARP-1 Collaboration

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this