Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory

Madeline M. Wong, Jung S. Byun, Maria Sacta, Qihuang Jin, Song Joon Baek, Kevin Gardner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A central hallmark of epigenetic inheritance is the parental transmission of changes in patterns of gene expression to progeny without modification of DNA sequence. Although, the trans-generational conveyance of this molecular memory has been traditionally linked to covalent modification of histone and/or DNA, recent studies suggest a role for proteins that persist or remain bound within chromatin to "bookmark" specific loci for enhanced or potentiated responses in daughter cells immediately following cell division. In this report we describe a role for p300 in enabling gene bookmarking by preinitiation complexes (PICs) containing RNA polymerase II (pol II), Mediator and TBP. Once formed these complexes require p300 to enable reacquisition of protein complex assemblies, chromatin modifications and long range chromatin interactions that facilitate post-mitotic transmission of transcriptional memory of prior environmental stimuli.

Original languageEnglish (US)
Article numbere99989
JournalPloS one
Issue number6
StatePublished - Jun 19 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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