Prolonged administration of oral etoposide plus cisplatin in extensive stage small cell lung cancer

F. A. Greco, P. B. Murphy, J. D. Hainsworth, K. R. Hande, D. H. Johnson

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4 Scopus citations


Etoposide is a highly schedule-dependent agent. We previously reported that a 21-day schedule of oral etoposide had good activity in small cell lung cancer (SCLC). The current phase II study was designed to test the combination of 21-day oral etoposide with cisplatin in hopes of capitalizing on etoposide's schedule dependency. Sixteen extensive stage SCLC patients were treated with cisplatin 100 mg/m2 day 1 plus 21 days of low-dose oral etoposide 50 mg/m2/day. Chemotherapy was repeated every 28 days for 4 cycles. Blood counts were monitored weekly, and etoposide was discontinued if the leukocyte or platelet count dropped below 2.0 x 109/l or 75 x 109/l, respectively. Fifteen of 16 patients were evaluable for response; 13 achieved either a complete (13%) or partial response (73%), for an overal] response rate of 86% (95% confidence interval, 62-93%). Median response duration was approximately 7 months; median survival was not reached. Thirteen patients (81%) received all the planned cycles of chemotherapy. In cycle 1 of chemotherapy, the median leukocyte nadir was 2.8 x 109/l (range, 0.1-6.3 x 109/l; median platelet nadir was 180 x 109/1 (range, 51-397 x 109/l). Life-threatening leukopenia (< 1.0 x 109/l) was unusual (2 of 58 cycles). There was 1 treatment-related death. One patient developed mild renal insufficiency that resolved after therapy. Nonhematologic toxicities were uncommon, but alopecia occurred in all patients. These data do not suggest that a major survival benefit will be derived for patients with extensive stage SCLC by increasing the duration of etoposide administration when used in combination with cisplatin. A randomized study is needed to determine if this long-term schedule of etoposide plus cisplatin is superior to the standard schedule of etoposide plus cisplatin.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
Issue numberSUPPL. 1
StatePublished - Jan 1 1992


  • Etoposide
  • Small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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