TY - JOUR
T1 - Prolactin levels in umbilical cord blood of human infants
T2 - Relation to gestational age, maternal complications, and neonatal lung function
AU - Parker, C. Richard
AU - MacDonald, Paul C.
AU - Guzick, David S.
AU - Porter, John C.
AU - Rosenfeld, Charles R.
AU - Hauth, John C.
N1 - Funding Information:
From the Department of Obstetrics and Gynecology, Umversity of Alabama at BIrmingham: and the Green Center for ReproductIve Biology Sciences and Departments of Obstetncs and Gynecology and Pedzatncs, Umverslty of Texas Southwestern MedIcal Schoof.! These studies were supported by grants HD22969 and HD13912 from the National InstItutes of Health. Presented at the Ninth Annual Meeting of the Society of Pennatal Obstetricians, New Orleans, LOUISIana, February 2-4, 1989. Reprint requests: C. Richard Parker, Jr., PhD, Department of Ob-stetrics and Gynecology, Untverstty of Alabama at Blrmzngham, UAB Station, BirmIngham, AL 35294. 6/6/14095
PY - 1989/9
Y1 - 1989/9
N2 - The ontogeny of serum prolactin and its relation to several variables, especially lung function, in 543 neonates was studied. Umbilical cord serum prolactin levels rose between 24 and 42 weeks' gestation, correlating significantly (p < 0.001) with gestational age (r = 0.44) and birth weight (r = 0.32). Among infants of similar ages, however, there was no variation in serum prolactin level as a function of birth weight, sex, Apgar scores, or delivery method. Infants of women with pregnancy-induced hypertension had higher than normal prolactin levels; infants of diabetic women had normal prolactin levels. At 31.5 to 37 weeks' gestation, infants who developed respiratory distress syndrome had lower serum prolactin levels than those whose lung function was normal or else was abnormal from causes other than respiratory distress syndrome. The risk for respiratory distress syndrome was higher in newborns whose prolactin level was low (10th percentile) than in infants whose prolactin level was high (90th percentile). These results are suggestive that prolactin may play a role in fetal lung maturation.
AB - The ontogeny of serum prolactin and its relation to several variables, especially lung function, in 543 neonates was studied. Umbilical cord serum prolactin levels rose between 24 and 42 weeks' gestation, correlating significantly (p < 0.001) with gestational age (r = 0.44) and birth weight (r = 0.32). Among infants of similar ages, however, there was no variation in serum prolactin level as a function of birth weight, sex, Apgar scores, or delivery method. Infants of women with pregnancy-induced hypertension had higher than normal prolactin levels; infants of diabetic women had normal prolactin levels. At 31.5 to 37 weeks' gestation, infants who developed respiratory distress syndrome had lower serum prolactin levels than those whose lung function was normal or else was abnormal from causes other than respiratory distress syndrome. The risk for respiratory distress syndrome was higher in newborns whose prolactin level was low (10th percentile) than in infants whose prolactin level was high (90th percentile). These results are suggestive that prolactin may play a role in fetal lung maturation.
KW - Prolactin
KW - human fetal lung
KW - hyaline membrane disease
KW - pregnancy
KW - respiratory distress syndrome (RDS)
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U2 - 10.1016/0002-9378(89)90404-3
DO - 10.1016/0002-9378(89)90404-3
M3 - Article
C2 - 2782363
AN - SCOPUS:0024423968
SN - 0002-9378
VL - 161
SP - 795
EP - 802
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -