Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films

Craig R. Saxton; Peter Gailiunas; J. Harold Helderman; Robert A. Farkas; Rosemary McCoy; Jan Diehl; Arthur I Sagalowsky; F. Kevin Murphy; Elliot D. Ross; Fred R. Silva; Duard L. Walker

doi:10.1016/0002-9343(84)90715-0

Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films

Craig R. Saxton, Peter Gailiunas, J. Harold Helderman, Robert A. Farkas, Rosemary McCoy, Jan Diehl, Arthur I Sagalowsky, F. Kevin Murphy, Elliot D. Ross, Fred R. Silva, Duard L. Walker

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A progressive, deteriorating neurologic disorder developed in a 28-year-old white man 10 years after he successfully received a living related donor kidney transplant. An extensive neurologic evaluation was unrevealing, including normal results of computed tomographic scanning of the brain with and without contrast medium. Repeated computed tomographic scanning after a double dose of radiocontrast medium in conjunction with delayed imaging revealed multiple areas of abnormal enhancement. This technique helped to direct brain biopsy, which led to the early diagnosis of progressive multifocal leukoencephalopathy and the institution of specific therapy.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	The American Journal of Medicine
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/0002-9343(84)90715-0
State	Published - Aug 1984

ASJC Scopus subject areas

Medicine(all)

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10.1016/0002-9343(84)90715-0

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Saxton, C. R., Gailiunas, P., Helderman, J. H., Farkas, R. A., McCoy, R., Diehl, J., Sagalowsky, A. I., Murphy, F. K., Ross, E. D., Silva, F. R., & Walker, D. L. (1984). Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films. The American Journal of Medicine, 77(2), 333-337. https://doi.org/10.1016/0002-9343(84)90715-0

Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films. / Saxton, Craig R.; Gailiunas, Peter; Helderman, J. Harold et al.
In: The American Journal of Medicine, Vol. 77, No. 2, 08.1984, p. 333-337.

Research output: Contribution to journal › Article › peer-review

Saxton, CR, Gailiunas, P, Helderman, JH, Farkas, RA, McCoy, R, Diehl, J, Sagalowsky, AI, Murphy, FK, Ross, ED, Silva, FR & Walker, DL 1984, 'Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films', The American Journal of Medicine, vol. 77, no. 2, pp. 333-337. https://doi.org/10.1016/0002-9343(84)90715-0

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abstract = "A progressive, deteriorating neurologic disorder developed in a 28-year-old white man 10 years after he successfully received a living related donor kidney transplant. An extensive neurologic evaluation was unrevealing, including normal results of computed tomographic scanning of the brain with and without contrast medium. Repeated computed tomographic scanning after a double dose of radiocontrast medium in conjunction with delayed imaging revealed multiple areas of abnormal enhancement. This technique helped to direct brain biopsy, which led to the early diagnosis of progressive multifocal leukoencephalopathy and the institution of specific therapy.",

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Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films

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