Progressive cranial polyneuropathy caused by primary central nervous system melanoma

L. A. Fish, D. I. Friedman, A. A. Sadun

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Primary malignant melanoma of the central nervous system (CNS) is exceedingly rare. The earliest description by Virchow in 1859 has been followed by ~ 50 autopsyproven cases reported in the literature. These tumors are considered to arise from leptomeningeal melanocytes whose embryonic origin is neural crest tissue. Given the rarity of primary CNS melanoma, the diagnosis requires a thorough search to exclude a dermatologic, ocular, or visceral site of tumor origin. We report an unusual case of primary CNS melanoma in a patient with painful, progressive cranial polyneuropathy that eluded ante- mortem diagnosis despite extensive clinical, radiograph- ical, and laboratory investigations.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalJournal of Clinical Neuro-Ophthalmology
Issue number1
StatePublished - Mar 1990


  • Primary central nervous system melanoma
  • Progressive cranial polyneuropathy

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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