Prognostic value of plasma fibroblast growth factor 21 among patients with acute ischemic stroke

Xiaowei Zheng, Zhengbao Zhu, Daoxia Guo, Chongke Zhong, Tan Xu, Yanbo Peng, Aili Wang, Hao Peng, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background and purpose: To evaluate the association between plasma fibroblast growth factor 21 (FGF-21) and clinical outcomes in patients with acute ischemic stroke. Methods: A total of 3412 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke with plasma FGF-21 measurements were included in this analysis. The primary outcome was a combination of death or major disability (modified Rankin Scale score ≥3) within 1 year after stroke. Results: During the 1-year of follow-up, 745 (21.83%) patients experienced the primary outcome; 550 had a major disability and 195 died. After multivariate adjustment, higher plasma FGF-21 was significantly associated with increased risk of the primary outcome (odds ratio = 1.52, 95% confidence interval = 1.11–1.29). Each 1-SD increase of log-transformed FGF-21 (0.67 pg/ml) was associated with 19%, 3%, and 33% increased risk of the primary outcome, major disability, and death, respectively. The addition of FGF-21 to the conventional risk factors significantly improved prediction of the primary outcome in ischemic stroke patients (net reclassification index = 10.8%, p = 0.011; integrated discrimination improvement = 0.3%, p = 0.038). Conclusions: Higher plasma FGF-21 was associated with poor prognosis in acute ischemic stroke patients, suggesting that FGF-21 may be a prognostic marker for ischemic stroke.

Original languageEnglish (US)
Pages (from-to)844-851
Number of pages8
JournalEuropean Journal of Neurology
Volume28
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • fibroblast growth factor 21
  • ischemic stroke
  • prognosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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