TY - JOUR
T1 - Prognostic significance of the initial electrocardiogram in patients with acute myocardial infarction
AU - Hathaway, William R.
AU - Peterson, Eric D.
AU - Wagner, Galen S.
AU - Granger, Christopher B.
AU - Zabel, K. Michael
AU - Pieper, Karen S.
AU - Clark, Kathryn Andersen
AU - Woodlief, Lynn H.
AU - Califf, Robert M.
PY - 1998/2/4
Y1 - 1998/2/4
N2 - Context. - Early risk stratification of patients with myocardial infarction is critical to determine optimum treatment strategies and enhance outcomes, but knowledge of the prognostic importance of the initial electrocardiogram (ECG) is limited. Objective. - To assess the independent value of the initial ECG for short-term risk stratification after acute myocardial infarction. Design. - Retrospective analysis of the Global Utilization of Streptokinase and t-PA (alteplase) for Occluded Coronary Arteries (GUSTO-I) clinical trial database. Setting. - A total of 1081 hospitals in 15 countries. Patients. - From the 41 021 patients enrolled in the overall study, we selected those who presented within 6 hours of chest pain onset with ST-segment elevation and no confounding factors (paced rhythms, ventricular rhythms, or left bundle-branch block) on the ECG performed before thrombolysis was administered (n=34 166). Main Outcome Measure. - Ability of initial ECG to predict all-cause mortality at 30 days. Results. - Most ECG variables were associated with 30-day mortality in a univariable analysis. In a multivariable analysis combining the initial ECG variables and clinical predictors of mortality, the sum of the absolute ST- segment deviation (both ST elevation and ST depression: odds ratio [OR], 1.53; 95% confidence interval [Cl], 1.38-1.69), ECG, heart rate (OR, 1.49; 95% Cl, 1.41-1.59), QRS duration (for anterior infarct: OR, 1.55; 95% Cl, 1.43-1.68), and ECG evidence of prior infarction (for new inferior infarct: OR, 2.47; 95% Cl, 2.02-3.00) were the strongest ECG predictors of mortality. A nomogram based on the multivariable model produced excellent discrimination of 30-day mortality (C-index, 0.830). Conclusions. - In patients presenting with myocardial infarction accompanied by ST-segment elevation, components of the initial ECG help predict 30-day mortality. This information should be valuable in early risk stratification, when the opportunity to reduce mortality is greatest, and may help in assessing outcomes adjusted for patient risk.
AB - Context. - Early risk stratification of patients with myocardial infarction is critical to determine optimum treatment strategies and enhance outcomes, but knowledge of the prognostic importance of the initial electrocardiogram (ECG) is limited. Objective. - To assess the independent value of the initial ECG for short-term risk stratification after acute myocardial infarction. Design. - Retrospective analysis of the Global Utilization of Streptokinase and t-PA (alteplase) for Occluded Coronary Arteries (GUSTO-I) clinical trial database. Setting. - A total of 1081 hospitals in 15 countries. Patients. - From the 41 021 patients enrolled in the overall study, we selected those who presented within 6 hours of chest pain onset with ST-segment elevation and no confounding factors (paced rhythms, ventricular rhythms, or left bundle-branch block) on the ECG performed before thrombolysis was administered (n=34 166). Main Outcome Measure. - Ability of initial ECG to predict all-cause mortality at 30 days. Results. - Most ECG variables were associated with 30-day mortality in a univariable analysis. In a multivariable analysis combining the initial ECG variables and clinical predictors of mortality, the sum of the absolute ST- segment deviation (both ST elevation and ST depression: odds ratio [OR], 1.53; 95% confidence interval [Cl], 1.38-1.69), ECG, heart rate (OR, 1.49; 95% Cl, 1.41-1.59), QRS duration (for anterior infarct: OR, 1.55; 95% Cl, 1.43-1.68), and ECG evidence of prior infarction (for new inferior infarct: OR, 2.47; 95% Cl, 2.02-3.00) were the strongest ECG predictors of mortality. A nomogram based on the multivariable model produced excellent discrimination of 30-day mortality (C-index, 0.830). Conclusions. - In patients presenting with myocardial infarction accompanied by ST-segment elevation, components of the initial ECG help predict 30-day mortality. This information should be valuable in early risk stratification, when the opportunity to reduce mortality is greatest, and may help in assessing outcomes adjusted for patient risk.
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U2 - 10.1001/jama.279.5.387
DO - 10.1001/jama.279.5.387
M3 - Article
C2 - 9459474
AN - SCOPUS:0032481356
SN - 0098-7484
VL - 279
SP - 387
EP - 391
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 5
ER -