Production of transgenic mice overexpressing rabbit Na+/H+ antiporter

M. Kuro-o, R. Nagai, Y. Yazaki, K. Hanaoka, Y. Nabeshima

Research output: Contribution to journalReview articlepeer-review


Recent investigations have raised a possibility that abnormal ion transportation through cell membranes may be involved in the pathogenesis of essential hypertension. In order to test the hypothesis that increased activity of Na+/H+ antiporter may cause hypertension, we developed transgenic mice overexpressing the Na+/H+ antiporter. We isolated a full-length cDNA clone encoding the rabbit Na+/H+ antiporter and constructed the transgene by ligating it with the human elongation factor 1 alpha promoter. We obtained three transgenic strains which express the transgene in various tissues such as kidney, heart and aorta. These transgenic mice may be useful for the analysis of pathogenesis of essential hypertension.

Original languageEnglish (US)
Pages (from-to)1524-1529
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number6
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Medicine(all)


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