Abstract
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.
| Original language | English (US) |
|---|---|
| Article number | 644593 |
| Journal | Frontiers in Human Neuroscience |
| Volume | 15 |
| DOIs | |
| State | Published - Apr 19 2021 |
| Externally published | Yes |
Keywords
- DBS (deep brain stimulation)
- adaptive DBS
- neuroethics
- neuroimaging
- novel hardware
- optogenetics
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Behavioral Neuroscience
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In: Frontiers in Human Neuroscience, Vol. 15, 644593, 19.04.2021.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank
T2 - Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies
AU - Vedam-Mai, Vinata
AU - Deisseroth, Karl
AU - Giordano, James
AU - Lazaro-Munoz, Gabriel
AU - Chiong, Winston
AU - Suthana, Nanthia
AU - Langevin, Jean Philippe
AU - Gill, Jay
AU - Goodman, Wayne
AU - Provenza, Nicole R.
AU - Halpern, Casey H.
AU - Shivacharan, Rajat S.
AU - Cunningham, Tricia N.
AU - Sheth, Sameer A.
AU - Pouratian, Nader
AU - Scangos, Katherine W.
AU - Mayberg, Helen S.
AU - Horn, Andreas
AU - Johnson, Kara A.
AU - Butson, Christopher R.
AU - Gilron, Ro’ee
AU - de Hemptinne, Coralie
AU - Wilt, Robert
AU - Yaroshinsky, Maria
AU - Little, Simon
AU - Starr, Philip
AU - Worrell, Greg
AU - Shirvalkar, Prasad
AU - Chang, Edward
AU - Volkmann, Jens
AU - Muthuraman, Muthuraman
AU - Groppa, Sergiu
AU - Kühn, Andrea A.
AU - Li, Luming
AU - Johnson, Matthew
AU - Otto, Kevin J.
AU - Raike, Robert
AU - Goetz, Steve
AU - Wu, Chengyuan
AU - Silburn, Peter
AU - Cheeran, Binith
AU - Pathak, Yagna J.
AU - Malekmohammadi, Mahsa
AU - Gunduz, Aysegul
AU - Wong, Joshua K.
AU - Cernera, Stephanie
AU - Wagle Shukla, Aparna
AU - Ramirez-Zamora, Adolfo
AU - Deeb, Wissam
AU - Patterson, Addie
AU - Foote, Kelly D.
AU - Okun, Michael S.
N1 - Funding Information: Funding. KD was supported by the National Institute on Drug Abuse (NIDA P50 Center), NIMH, DARPA, the Tarlton Foundation, the AE Foundation Borderline Research Fund, the NOMIS Foundation, the Else Kroner Fresenius Foundation and the NSF NeuroNex program. JamG was supported in part by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Leadership Initiatives, NeurGen, BNB corporation, and the Creighton University Medical Visiting Professorship and receives federal funds from the National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards Program, part of the Roadmap Initiative, Re-Engineering the Clinical Research Enterprise. GL-M was supported by the National Institutes of Health (R01MH114854). WC was supported by the National Institute of Mental Health of the National Institutes of Health under award [Number R01MH114860]. NS was supported by the NIH (NINDS UO1 NS103802) and the McKnight Foundation (Technological Innovations in Neuroscience Award). J-PL was supported by the NIH (NIMH UH3 NS107673). WG was supported by the NIH (NINDS UH3 NS100549). CHH was supported by the NIH (NINDS UH3 NS103446). SS was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS103549. NRP was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS103549. This work was supported by National Institutes of Health award K23NS110962, NARSAD Young Investigator grant from the Brain and Behavioral Research Foundation (KS), and a Ray and Dagmar Dolby Family Fund through the Department of Psychiatry at the University of California, San Francisco. HM was supported by the NIH (UH3 NS103550-02) and Hope for Depression Research Foundation. AH was supported by the German Research Foundation (DFG Grants 410169619 and 424778381 – TRR 295). KJ was supported by the NSF Graduate Research Fellowship Program (1747505) and NIH P41 Center for Integrative Biomedical Computing (CIBC) (GM103545). CB was supported by NIH P41 Center for Integrative Biomedical Computing (CIBC) (GM103545) and NIH NINR (NR014852). RG was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS100544. RW was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS100544. PhS was supported by NIH BRAIN (UH3NS109556 and UH3NS100544). GW was supported by the NIH (R01 NS092882 & UH3 NS095495). PrS and EC were supported by NIH HEAL (UH3NS115631) and NIH BRAIN (UH3NS109556). EC was supported by NIH BRAIN (UH3NS109556). This work was supported by the German Research Foundation (DFG; SFB-TR-128, SFB-CRC 1193) and the Boehringer Ingelheim Fonds (BIF-03) (MuM and SeG). The work presented at the Think Tank was supported by the National Key Research and Development Program of China (2016YFC0105900), the National Natural Science Foundation of China (61901243) and the Research and Development Program of Beijing (LL). This work was supported in part by NIH grants R01-NS081118, R01-NS094206, P50-NS098573, and R25-NS118756 (MJ). Funding for the work was provided by Abbott (CW and PeS). JKW is supported by NIH (R25NS108939). Funding Information: KD was supported by the National Institute on Drug Abuse (NIDA P50 Center), NIMH, DARPA, the Tarlton Foundation, the AE Foundation Borderline Research Fund, the NOMIS Foundation, the Else Kroner Fresenius Foundation and the NSF NeuroNex program. JamG was supported in part by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Leadership Initiatives, NeurGen, BNB corporation, and the Creighton University Medical Visiting Professorship and receives federal funds from the National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards Program, part of the Roadmap Initiative, Re-Engineering the Clinical Research Enterprise. GL-M was supported by the National Institutes of Health (R01MH114854). WC was supported by the National Institute of Mental Health of the National Institutes of Health under award [Number R01MH114860]. NS was supported by the NIH (NINDS UO1 NS103802) and the McKnight Foundation (Technological Innovations in Neuroscience Award). J-PL was supported by the NIH (NIMH UH3 NS107673). WG was supported by the NIH (NINDS UH3 NS100549). CHH was supported by the NIH (NINDS UH3 NS103446). SS was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS103549. NRP was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS103549. This work was supported by National Institutes of Health award K23NS110962, NARSAD Young Investigator grant from the Brain and Behavioral Research Foundation (KS), and a Ray and Dagmar Dolby Family Fund through the Department of Psychiatry at the University of California, San Francisco. HM was supported by the NIH (UH3 NS103550-02) and Hope for Depression Research Foundation. AH was supported by the German Research Foundation (DFG Grants 410169619 and 424778381 – TRR 295). KJ was supported by the NSF Graduate Research Fellowship Program (1747505) and NIH P41 Center for Integrative Biomedical Computing (CIBC) (GM103545). CB was supported by NIH P41 Center for Integrative Biomedical Computing (CIBC) (GM103545) and NIH NINR (NR014852). RG was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS100544. RW was supported by the NIH BRAIN Initiative via the cooperative agreement UH3NS100544. PhS was supported by NIH BRAIN (UH3NS109556 and UH3NS100544). GW was supported by the NIH (R01 NS092882 & UH3 NS095495). PrS and EC were supported by NIH HEAL (UH3NS115631) and NIH BRAIN (UH3NS109556). EC was supported by NIH BRAIN (UH3NS109556). This work was supported by the German Research Foundation (DFG; SFB-TR-128, SFB-CRC 1193) and the Boehringer Ingelheim Fonds (BIF-03) (MuM and SeG). The work presented at the Think Publisher Copyright: © Copyright © 2021 Vedam-Mai, Deisseroth, Giordano, Lazaro-Munoz, Chiong, Suthana, Langevin, Gill, Goodman, Provenza, Halpern, Shivacharan, Cunningham, Sheth, Pouratian, Scangos, Mayberg, Horn, Johnson, Butson, Gilron, de Hemptinne, Wilt, Yaroshinsky, Little, Starr, Worrell, Shirvalkar, Chang, Volkmann, Muthuraman, Groppa, Kühn, Li, Johnson, Otto, Raike, Goetz, Wu, Silburn, Cheeran, Pathak, Malekmohammadi, Gunduz, Wong, Cernera, Wagle Shukla, Ramirez-Zamora, Deeb, Patterson, Foote and Okun.
PY - 2021/4/19
Y1 - 2021/4/19
N2 - We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.
AB - We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank.
KW - DBS (deep brain stimulation)
KW - adaptive DBS
KW - neuroethics
KW - neuroimaging
KW - novel hardware
KW - optogenetics
UR - http://www.scopus.com/inward/record.url?scp=85105279727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105279727&partnerID=8YFLogxK
U2 - 10.3389/fnhum.2021.644593
DO - 10.3389/fnhum.2021.644593
M3 - Article
C2 - 33953663
AN - SCOPUS:85105279727
SN - 1662-5161
VL - 15
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
M1 - 644593
ER -