Problems with the use of diuretics in the treatment of hypertension

Considerable data support the view that diuretics, in large part by their induction of both potassium and magnesium depletion, are capable of considerable mischief. Much of this mischief may be avoided by careful use of diuretics, in the smallest effective dose, with concomitant dietary sodium restriction and monitoring of serum electrolytes. But another alternative, equally appropriate for the large population of mild hypertensives who should have an adequate fall in blood pressure with one of a number of other drugs, is not to choose a diuretic as the initial drug.