@article{54f4fa92af9e480989e0d1b2bd2a451a,
title = "Probing for a deeper understanding of rhabdomyosarcoma: Insights from complementary model systems",
abstract = "Rhabdomyosarcoma (RMS) is a mesenchymal malignancy composed of neoplastic primitive precursor cells that exhibit histological features of myogenic differentiation. Despite intensive conventional multimodal therapy, patients with high-risk RMS typically suffer from aggressive disease. The lack of directed therapies against RMS emphasizes the need to further uncover the molecular underpinnings of the disease. In this Review, we discuss the notable advances in the model systems now available to probe for new RMS-targetable pathogenetic mechanisms, and the possibilities for enhanced RMS therapeutics and improved clinical outcomes.",
author = "Kashi, {Venkatesh P.} and Hatley, {Mark E.} and Galindo, {Rene L.}",
note = "Funding Information: We apologize to the many authors who have done important work on rhabdomyosarcoma (RMS) that we were unable to cite owing to space constraints. This work was supported in part by grants from the US National Cancer Institute (K08CA151649) and American Lebanese Syrian Associated Charities (to M.E.H.), the American Cancer Society Research Scholars Award (to R.L.G.), the Burroughs Wellcome Fund Career Award for Medical Scientists (to R.L.G.), and the Alex{\textquoteright}s Lemonade Stand Foundation “A” Award (to R.L.G.). The pleomorphic RMS image was kindly provided by P. Kapur. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited.",
year = "2015",
month = jul,
day = "26",
doi = "10.1038/nrc3961",
language = "English (US)",
volume = "15",
pages = "426--439",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "7",
}