Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Sarah K. Kaufman, Marc I. Diamond

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
Issue number3
StatePublished - Jul 2013


  • Networks
  • Neurodegeneration
  • Prion
  • Templated conformational change
  • Trans-cellular propagation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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