Primate neostriatal neurons containing tyrosine hydroxylase: Immunohistochemical evidence

Mark Dubach, Richard Schmidt, Dennis Kunkel, Douglas M. Bowden, Richard Martin, Dwight C. German

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We have detected, in monkey caudate nucleus and putamen, neuronal cell bodies containing tyrosine hydroxylase-like immunoreactivity, as revealed by peroxidase-antiperoxidase immunohistochemistry. Many of these cells are distributed in an outer rim of 1-2 mm throughout the anterior-posterior extent of the neostriatum near its borders with the corona radiata; others are embedded in the adjacent white matter, especially near the ventral putamen and nucleus accumbens. Light and electron microscopy indicate that they are small (8-12 μm), bipolar cells with large nuclei. Such neostriatal neurons, containing tyrosine hydroxylase-like immunoreactivity, number in the tens of thousands.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalNeuroscience letters
Issue number2
StatePublished - Mar 31 1987


  • Caudate
  • Dopamine
  • Dopamine β-hydroxylase
  • Macaque
  • Monkey
  • Putamen
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)


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