Primary sclerosing cholangitis: Updates in diagnosis and therapy

Piero Portincasa, Michele Vacca, Antonio Moschetta, Michele Petruzzelli, Giuseppe Palasciano, Karel J. van Erpecum, Gerard P. van Berge-Henegouwen

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number1
StatePublished - Jan 7 2005


  • Diagnosis
  • Sclerosing cholangitis
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology


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