Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy

Katsunaka Mikami; Ricardo E. Jorge; David J. Moser; Stephan Arndt; Mijin Jang; Ana Solodkin; Steven L. Small; Pasquale Fonzetti; Mark T. Hegel; Robert G. Robinson

doi:10.1176/appi.neuropsych.11020047

Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy

Katsunaka Mikami, Ricardo E. Jorge, David J. Moser, Stephan Arndt, Mijin Jang, Ana Solodkin, Steven L. Small, Pasquale Fonzetti, Mark T. Hegel, Robert G. Robinson

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.

Original language	English (US)
Pages (from-to)	323-328
Number of pages	6
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	26
Issue number	4
DOIs	https://doi.org/10.1176/appi.neuropsych.11020047
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy",

abstract = "This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.",

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AU - Mikami, Katsunaka

AU - Jorge, Ricardo E.

AU - Moser, David J.

AU - Arndt, Stephan

AU - Jang, Mijin

AU - Solodkin, Ana

AU - Small, Steven L.

AU - Fonzetti, Pasquale

AU - Hegel, Mark T.

AU - Robinson, Robert G.

PY - 2014

Y1 - 2014

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Prevention of post-stroke generalized anxiety disorder, Using escitalopram or problem- solving therapy

Abstract

ASJC Scopus subject areas

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