Prevention of neonatal group B streptococcal disease: A combined intrapartum and neonatal protocol

George D. Wendel, Kenneth J. Leveno, Pablo J. Sánchez, Gregory L. Jackson, Donald D. McIntire, Jane D. Siegel

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


OBJECTIVE: We sought to assess the efficacy of a clinical protocol to reduce the incidence of early-onset neonatal group B Streptococcus (GBS) infection. STUDY DESIGN: We assessed neonatal sepsis from GBS and other organisms with use of a before-after study design to evaluate the effects of implementation of combined intrapartum antimicrobial prophylaxis given selectively to mothers with GBS risks and penicillin G given to all neonates. RESULTS: In 1994, early-onset GBS infection developed in 31 of 13,887 live births (2.2/1000), 13 preterm and 18 term cases. After implementation of the prophylaxis protocol (1995), 6 of 13,527 live births had early-onset GBS (0.4/1000) (P < .001). There were no preterm (P = .0004) and 6 term GBS cases (P = .02). The efficacy continued through 1999 (0.5/1000) without an increase in neonatal infections from other bacteria. CONCLUSION: Combined maternal and infant antimicrobial prophylaxis can significantly and safely reduce rates of early-onset GBS infection in both preterm and term infants.

Original languageEnglish (US)
Pages (from-to)618-626
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - 2002


  • Ampicillin
  • Group B Streptococcus
  • Neonatal sepsis
  • Penicillin G

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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