Prevention of cardiac hypertrophy in mice by calcineurin inhibition

Mark A. Sussman; Hae W. Lim; Natalie Gude; Tyler Taigen; Eric N. Olson; Jeffrey Robbins; Melissa C. Colbert; Antonio Gualberto; David F. Wieczorek; Jeffery D. Molkentin

doi:10.1126/science.281.5383.1690

Prevention of cardiac hypertrophy in mice by calcineurin inhibition

Mark A. Sussman, Hae W. Lim, Natalie Gude, Tyler Taigen, Eric N. Olson, Jeffrey Robbins, Melissa C. Colbert, Antonio Gualberto, David F. Wieczorek, Jeffery D. Molkentin

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Abstract

Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal β-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model or pressure-overload hypertrophy. These results suggest that calcineurin inhibitors.

Original language	English (US)
Pages (from-to)	1690-1693
Number of pages	4
Journal	Science
Volume	281
Issue number	5383
DOIs	https://doi.org/10.1126/science.281.5383.1690
State	Published - Sep 11 1998

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title = "Prevention of cardiac hypertrophy in mice by calcineurin inhibition",

abstract = "Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal β-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model or pressure-overload hypertrophy. These results suggest that calcineurin inhibitors.",

author = "Sussman, {Mark A.} and Lim, {Hae W.} and Natalie Gude and Tyler Taigen and Olson, {Eric N.} and Jeffrey Robbins and Colbert, {Melissa C.} and Antonio Gualberto and Wieczorek, {David F.} and Molkentin, {Jeffery D.}",

year = "1998",

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doi = "10.1126/science.281.5383.1690",

language = "English (US)",

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T1 - Prevention of cardiac hypertrophy in mice by calcineurin inhibition

AU - Sussman, Mark A.

AU - Lim, Hae W.

AU - Gude, Natalie

AU - Taigen, Tyler

AU - Olson, Eric N.

AU - Robbins, Jeffrey

AU - Colbert, Melissa C.

AU - Gualberto, Antonio

AU - Wieczorek, David F.

AU - Molkentin, Jeffery D.

PY - 1998/9/11

Y1 - 1998/9/11

N2 - Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal β-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model or pressure-overload hypertrophy. These results suggest that calcineurin inhibitors.

AB - Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal β-tropomyosin in the heart. Cyclosporin had a similar effect in a rat model or pressure-overload hypertrophy. These results suggest that calcineurin inhibitors.

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Prevention of cardiac hypertrophy in mice by calcineurin inhibition

Abstract

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