Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

Nathan M. Krah; Shuba M. Narayanan; Deanne E. Yugawa; Julie A. Straley; Christopher V.E. Wright; Raymond J. MacDonald; L. Charles Murtaugh

doi:10.1016/j.devcel.2019.07.012

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

Nathan M. Krah, Shuba M. Narayanan, Deanne E. Yugawa, Julie A. Straley, Christopher V.E. Wright, Raymond J. MacDonald, L. Charles Murtaugh

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces quiescence and re-differentiation.

Original language	English (US)
Pages (from-to)	744-754.e4
Journal	Developmental cell
Volume	50
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2019.07.012
State	Published - Sep 23 2019

Keywords

Kras
Ptf1a
acinar cell
differentiation
pancreas
pancreatic cancer

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.07.012

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title = "Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism",

abstract = "Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces quiescence and re-differentiation.",

keywords = "Kras, Ptf1a, acinar cell, differentiation, pancreas, pancreatic cancer",

author = "Krah, {Nathan M.} and Narayanan, {Shuba M.} and Yugawa, {Deanne E.} and Straley, {Julie A.} and Wright, {Christopher V.E.} and MacDonald, {Raymond J.} and Murtaugh, {L. Charles}",

note = "Funding Information: We are grateful to members of our laboratories as well as Howard Crawford, Gabrielle Kardon, and Matthew Firpo for helpful input. This work was supported by the National Institutes of Health through the following grants: F30-CA192819 (N.M.K.), R01-DK061220 , R01-CA194941 (L.C.M. and R.J.M.), and U01-DK089570 (C.V.E.W.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "23",

doi = "10.1016/j.devcel.2019.07.012",

language = "English (US)",

volume = "50",

pages = "744--754.e4",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

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T1 - Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

AU - Krah, Nathan M.

AU - Narayanan, Shuba M.

AU - Yugawa, Deanne E.

AU - Straley, Julie A.

AU - Wright, Christopher V.E.

AU - MacDonald, Raymond J.

AU - Murtaugh, L. Charles

N1 - Funding Information: We are grateful to members of our laboratories as well as Howard Crawford, Gabrielle Kardon, and Matthew Firpo for helpful input. This work was supported by the National Institutes of Health through the following grants: F30-CA192819 (N.M.K.), R01-DK061220 , R01-CA194941 (L.C.M. and R.J.M.), and U01-DK089570 (C.V.E.W.). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/9/23

Y1 - 2019/9/23

N2 - Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces quiescence and re-differentiation.

AB - Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces quiescence and re-differentiation.

KW - Kras

KW - Ptf1a

KW - acinar cell

KW - differentiation

KW - pancreas

KW - pancreatic cancer

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UR - http://www.scopus.com/inward/citedby.url?scp=85072256238&partnerID=8YFLogxK

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DO - 10.1016/j.devcel.2019.07.012

M3 - Article

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AN - SCOPUS:85072256238

SN - 1534-5807

VL - 50

SP - 744-754.e4

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

Abstract

Keywords

ASJC Scopus subject areas

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