Prevalence of noncardiac structural anomalies in twin-twin transfusion syndrome

Shivani Patel, Linda M. Randolph, Kurt Benirschke, Arlyn Llanes, Larisa Yedigarova, Ramen H. Chmait

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives - Compared to singleton pregnancies, monochorionic twins have increased rates of perinatal morbidity and mortality, believed due in part to both twin-twin transfusion syndrome and an increased risk of congenital anomalies. Here we describe the prevalence of noncardiac structural anomalies in monochorionic twins with twin-twin transfusion syndrome who underwent laser surgery. Methods - In a retrospective study of 221 consecutive cases of twin-twin transfusion syndrome treated with laser surgery, noncardiac anomalies were identified by review of antepartum and neonatal medical records. Results - Of 377 live-born twins, 19 (5.0%) had a noncardiac anomaly. This rate was increased for donor versus recipient twins (8.5% versus 2.0%; P< .01). The presence of an anomaly was unrelated to the Quintero stage, the presence of donor intrauterine growth restriction, or 30-day survival of the donor or recipient. Conclusions - The prevalence of noncardiac anomalies in pregnancies complicated by twin-twin transfusion syndrome who underwent laser surgery was higher in donors versus recipients.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalJournal of Ultrasound in Medicine
Issue number4
StatePublished - Apr 1 2012


  • Congenital anomaly
  • Monochorionic twins
  • Twin-twin transfusion syndrome

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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