Presence of contractile-type smooth muscle cells in the endocardium

T. Suzuki, M. Aikawa, M. Kuro-o, M. Watanabe, K. Kimura, Y. Yazaki, R. Nagai

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A smooth muscle layer exists in the parietal endocardium. Notwithstanding previous pioneer work, little has been known on the phenotypes of these smooth muscles. In humans as in animals, smooth muscles show two distinct phenotypes, the ‘synthetic’ and ‘contractile’ states, which can be differentiated on the basis of the expression of two types of myosin heavy chain isoforms, SMI and SM2. In this study, using SMI- and SM2-specific monoclonal antibodies, we performed immunohistochemical examinations to determine the phenotype of the endocardial smooth muscles. We report here that the endocardial smooth muscles have the contractile phenotype.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalCardiology (Switzerland)
Issue number1
StatePublished - Jan 1 1996


  • Contractile phenotype
  • Endocardium
  • Smooth muscle cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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