Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases

Anthony J. Di Pasqua; James E. Huckle; Jin Ki Kim; Younjee Chung; Andrew Z. Wang; Michael Jay; Xiuling Lu

doi:10.1002/smll.201102488

Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases

Anthony J. Di Pasqua, James E. Huckle, Jin Ki Kim, Younjee Chung, Andrew Z. Wang, Michael Jay, Xiuling Lu

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Nanoparticles containing stable holmium ( ¹⁶⁵Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield ¹⁶⁶Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the ¹⁶⁶Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.

Original language	English (US)
Pages (from-to)	997-1000
Number of pages	4
Journal	Small
Volume	8
Issue number	7
DOIs	https://doi.org/10.1002/smll.201102488
State	Published - Apr 10 2012
Externally published	Yes

Keywords

drug delivery
holmium
imaging
nanoparticle
ovarian cancer

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Biotechnology
Biomaterials

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10.1002/smll.201102488

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title = "Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases",

abstract = "Nanoparticles containing stable holmium ( 165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.",

keywords = "drug delivery, holmium, imaging, nanoparticle, ovarian cancer",

author = "{Di Pasqua}, {Anthony J.} and Huckle, {James E.} and Kim, {Jin Ki} and Younjee Chung and Wang, {Andrew Z.} and Michael Jay and Xiuling Lu",

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AU - Di Pasqua, Anthony J.

AU - Huckle, James E.

AU - Kim, Jin Ki

AU - Chung, Younjee

AU - Wang, Andrew Z.

AU - Jay, Michael

AU - Lu, Xiuling

PY - 2012/4/10

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AB - Nanoparticles containing stable holmium ( 165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.

KW - drug delivery

KW - holmium

KW - imaging

KW - nanoparticle

KW - ovarian cancer

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Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases

Abstract

Keywords

ASJC Scopus subject areas

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