TY - JOUR
T1 - Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent
AU - Chen, Xiangji
AU - Guo, Yunhang
AU - Zhang, Qiuyan
AU - Hao, Guiyang
AU - Jia, Hongmei
AU - Liu, Boli
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 20471011) and Beijing Municipal Commission of Education. We also thank Beijing Shihong Pharmaceutical Center for providing MIBI kit and Cu(MIBI) 4 BF 4 .
PY - 2008/5/1
Y1 - 2008/5/1
N2 - 99mTc-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [99mTc(CO)3(MIBI)3]+ demonstrated a significant location in myocardium with a lower liver uptake as compared with 99mTc-Sestamibi. In this work, we found that new [99mTc(CO)2(MIBI)4]+ could be prepared with high radiochemical purity. The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated and biodistribution was performed to evaluate the [99mTc(CO)2(MIBI)4]+ as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.
AB - 99mTc-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [99mTc(CO)3(MIBI)3]+ demonstrated a significant location in myocardium with a lower liver uptake as compared with 99mTc-Sestamibi. In this work, we found that new [99mTc(CO)2(MIBI)4]+ could be prepared with high radiochemical purity. The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated and biodistribution was performed to evaluate the [99mTc(CO)2(MIBI)4]+ as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.
KW - MIBI
KW - Myocardial imaging
KW - Tricarbonyl technetium
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U2 - 10.1016/j.jorganchem.2008.02.006
DO - 10.1016/j.jorganchem.2008.02.006
M3 - Article
AN - SCOPUS:41849119061
SN - 0022-328X
VL - 693
SP - 1822
EP - 1828
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
IS - 10
ER -