Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging

Guiyang Hao; Jianying Zang; Boli Liu

doi:10.1002/jlcr.1151

Preparation and biodistribution of novel ^99mTc(CO) ₃-CNR complexes for myocardial imaging

Guiyang Hao, Jianying Zang, Boli Liu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We evaluated lipophilicity and biodistribution of a series of ^99mTc(CO)₃-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel ^99mTc(CO)₃-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like ^99mTc(CO) ₃-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [^99mTc(CO)₃(MIBI)₃] ⁺ though their heart uptake was not so high. Among these complexes, [^99mTc(CO)₃(EPI)₂(OH₂)]⁺ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [^99mTc(CO)₃(MIBI)₃]⁺.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	50
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.1151
State	Published - Jan 2007

Keywords

Isonitrile
Myocardial imaging
Tc-99m
Tricarbonyl

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.1151

Cite this

@article{48bd3020ce1a4854b83a418041fbef91,

title = "Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging",

abstract = "We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO) 3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3] + though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+.",

keywords = "Isonitrile, Myocardial imaging, Tc-99m, Tricarbonyl",

author = "Guiyang Hao and Jianying Zang and Boli Liu",

year = "2007",

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doi = "10.1002/jlcr.1151",

language = "English (US)",

volume = "50",

pages = "13--18",

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T1 - Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging

AU - Hao, Guiyang

AU - Zang, Jianying

AU - Liu, Boli

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N2 - We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO) 3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3] + though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+.

AB - We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO) 3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3] + though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+.

KW - Isonitrile

KW - Myocardial imaging

KW - Tc-99m

KW - Tricarbonyl

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