Preoperative cortical localization with functional MRI for use in stereotactic radiosurgery

Thomas C. Witt, Douglas Kondziolka, Stephen B. Baumann, Douglas C. Noll, Steven L. Small, L. Dade Limsford

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Accurate localization of the lesion with respect to functionally significant brain is essential to safe stereotactic radiosurgical dose planning. We report the use of functional MR imaging in 3 patients to identify critical areas of surrounding brain and to provide assistance with dose planning, especially with regard to shaping the peripheral isodose around the lesion. We used a functional MRI system employing a conventional 1.5-tesla MRI unit that can detect decreases in deoxyhemoglobin concentration occurring with performance of specific tasks. Two of the patients had supratentorial arteriovenous malformations and 1 patient had a recurrent parasagittal meningioma. Functional MRI provided information on the location of speech, motor, and sensory cortex in these patients. Radiosurgical dose plans were constructed that kept these cortical areas outside of the 30% isodose curves. We believe that the safety of supratentorial parenchymal radiosurgery will be enhanced by the localization of critical brain regions around the target.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalStereotactic and Functional Neurosurgery
Issue number1-3
StatePublished - Oct 1996
Externally publishedYes


  • Cortical mapping
  • Functional MRI
  • Radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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