Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

Matthew J. Krasin; Andrew M. Davidoff; Xiaoping Xiong; Shengjie Wu; Chia H. Hua; Fariba Navid; Carlos Rodriguez-Galindo; Bhaskar N. Rao; Kelly A. Hoth; Michael D. Neel; Thomas E. Merchant; Larry E. Kun; Sheri L. Spunt

doi:10.1016/j.ijrobp.2009.02.074

Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

Matthew J. Krasin, Andrew M. Davidoff, Xiaoping Xiong, Shengjie Wu, Chia H. Hua, Fariba Navid, Carlos Rodriguez-Galindo, Bhaskar N. Rao, Kelly A. Hoth, Michael D. Neel, Thomas E. Merchant, Larry E. Kun, Sheri L. Spunt

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

Original language	English (US)
Pages (from-to)	874-878
Number of pages	5
Journal	International Journal of Radiation Oncology Biology Physics
Volume	76
Issue number	3
DOIs	https://doi.org/10.1016/j.ijrobp.2009.02.074
State	Published - Mar 1 2010

Keywords

Conformal
IMRT
Margin
Radiation
Soft-tissue sarcoma

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.ijrobp.2009.02.074

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Krasin, M. J., Davidoff, A. M., Xiong, X., Wu, S., Hua, C. H., Navid, F., Rodriguez-Galindo, C., Rao, B. N., Hoth, K. A., Neel, M. D., Merchant, T. E., Kun, L. E., & Spunt, S. L. (2010). Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma. International Journal of Radiation Oncology Biology Physics, 76(3), 874-878. https://doi.org/10.1016/j.ijrobp.2009.02.074

Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma. / Krasin, Matthew J.; Davidoff, Andrew M.; Xiong, Xiaoping et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 76, No. 3, 01.03.2010, p. 874-878.

Research output: Contribution to journal › Article › peer-review

Krasin, MJ, Davidoff, AM, Xiong, X, Wu, S, Hua, CH, Navid, F, Rodriguez-Galindo, C, Rao, BN, Hoth, KA, Neel, MD, Merchant, TE, Kun, LE & Spunt, SL 2010, 'Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma', International Journal of Radiation Oncology Biology Physics, vol. 76, no. 3, pp. 874-878. https://doi.org/10.1016/j.ijrobp.2009.02.074

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title = "Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma",

abstract = "Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.",

keywords = "Conformal, IMRT, Margin, Radiation, Soft-tissue sarcoma",

author = "Krasin, {Matthew J.} and Davidoff, {Andrew M.} and Xiaoping Xiong and Shengjie Wu and Hua, {Chia H.} and Fariba Navid and Carlos Rodriguez-Galindo and Rao, {Bhaskar N.} and Hoth, {Kelly A.} and Neel, {Michael D.} and Merchant, {Thomas E.} and Kun, {Larry E.} and Spunt, {Sheri L.}",

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doi = "10.1016/j.ijrobp.2009.02.074",

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AU - Xiong, Xiaoping

AU - Wu, Shengjie

AU - Hua, Chia H.

AU - Navid, Fariba

AU - Rodriguez-Galindo, Carlos

AU - Rao, Bhaskar N.

AU - Hoth, Kelly A.

AU - Neel, Michael D.

AU - Merchant, Thomas E.

AU - Kun, Larry E.

AU - Spunt, Sheri L.

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N2 - Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

AB - Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Methods and Materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin. Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was ≥97% of the prescribed dose. Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.

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KW - Radiation

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Preliminary Results From a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients With High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma

Abstract

Keywords

ASJC Scopus subject areas

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