Preliminary biochemical investigations of the intermediate filaments

John E. Rash, Jerry W. Shay, John J. Biesele

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Preliminary biochemical investigations of differentiating cardiac muscle first revealed the occurrence of a third class of filaments, differing in appearance and reactivities from the thick and thin filaments of the sarcomere. These intermediate filaments were more resistant to extraction with neutral salts, β-mer-captoethanol, and urea than were the thick filaments, thin filaments, or Z material. Combined with the data from the accompanying report, sufficient evidence is presented to discount virtually all previous models of myofibrillogenesis.

Original languageEnglish (US)
Pages (from-to)399-407
Number of pages9
JournalJournal of Ultrasructure Research
Issue number5-6
StatePublished - Dec 1970

ASJC Scopus subject areas

  • Anatomy
  • Molecular Biology


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