TY - JOUR
T1 - Pregnancy and child health outcomes in pediatric and young adult leukemia and lymphoma survivors
T2 - a systematic review
AU - Shliakhtsitsava, Ksenya
AU - Romero, Sally A.D.
AU - Dewald, Samantha Rose
AU - Su, H. Irene
N1 - Funding Information:
This study was supported in part by the Doris Howell Foundation Community Engagement Initiative, the California Breast Cancer Research Program Translational Award 200B-0 144, and National Institutes of Health grant HD080952-03. The content is solely the responsibility of the authors and does not necessarily represent official views of the funding organizations.
Funding Information:
This study was supported in part by the Doris Howell Foundation Community Engagement Initiative, the California Breast Cancer Research Program Translational Award 200B-0 144, and National Institutes of Health grant HD080952-03.
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - As long-term survival is high for children and young adults diagnosed with leukemia and lymphoma, delineating maternal, fetal and offspring health risks is important to their family planning. This systematic review examined data comparing these health risks between leukemia and lymphoma survivors and women without a history of cancer. Following a search of Embase, PubMed, CINAHL, Cochrane, and Web of Science, 142 articles were screened and 18 were included in this review. No higher risks of spontaneous abortion, maternal diabetes and anemia, stillbirth, birth defects, or childhood cancer in offspring were observed in survivors compared to controls. Important to counseling and clinical care, live birth rates were lower, while preterm birth and low birth weight risks were modestly higher in survivors compared to controls. Findings were largely reassuring but highlight the lack of data on maternal cardiopulmonary risks, differential risk by cancer treatment type, and interventions to decrease these risks.
AB - As long-term survival is high for children and young adults diagnosed with leukemia and lymphoma, delineating maternal, fetal and offspring health risks is important to their family planning. This systematic review examined data comparing these health risks between leukemia and lymphoma survivors and women without a history of cancer. Following a search of Embase, PubMed, CINAHL, Cochrane, and Web of Science, 142 articles were screened and 18 were included in this review. No higher risks of spontaneous abortion, maternal diabetes and anemia, stillbirth, birth defects, or childhood cancer in offspring were observed in survivors compared to controls. Important to counseling and clinical care, live birth rates were lower, while preterm birth and low birth weight risks were modestly higher in survivors compared to controls. Findings were largely reassuring but highlight the lack of data on maternal cardiopulmonary risks, differential risk by cancer treatment type, and interventions to decrease these risks.
KW - Leukemia
KW - cancer survivorship
KW - child health
KW - lymphoma
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85025454756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025454756&partnerID=8YFLogxK
U2 - 10.1080/10428194.2017.1352097
DO - 10.1080/10428194.2017.1352097
M3 - Article
C2 - 28728448
AN - SCOPUS:85025454756
SN - 1042-8194
VL - 59
SP - 381
EP - 397
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 2
ER -