TY - JOUR
T1 - Prefrontal-subthalamic theta signaling mediates delayed responses during conflict processing
AU - Choi, Jeong Woo
AU - Malekmohammadi, Mahsa
AU - Niketeghad, Soroush
AU - Cross, Katy A.
AU - Ebadi, Hamasa
AU - Alijanpourotaghsara, Amirreza
AU - Aron, Adam
AU - Rutishauser, Ueli
AU - Pouratian, Nader
N1 - Publisher Copyright:
© 2024
PY - 2024/5
Y1 - 2024/5
N2 - While medial frontal cortex (MFC) and subthalamic nucleus (STN) have been implicated in conflict monitoring and action inhibition, respectively, an integrated understanding of the spatiotemporal and spectral interaction of these nodes and how they interact with motor cortex (M1) to definitively modify motor behavior during conflict is lacking. We recorded neural signals intracranially across presupplementary motor area (preSMA), M1, STN, and globus pallidus internus (GPi), during a flanker task in 20 patients undergoing deep brain stimulation implantation surgery for Parkinson disease or dystonia. Conflict is associated with sequential and causal increases in local theta power from preSMA to STN to M1 with movement delays directly correlated with increased STN theta power, indicating preSMA is the MFC locus that monitors conflict and signals STN to implement a ‘break.’ Transmission of theta from STN-to-M1 subsequently results in a transient increase in M1-to-GPi beta flow immediately prior to movement, modulating the motor network to actuate the conflict-related action inhibition (i.e., delayed response). Action regulation during conflict relies on two distinct circuits, the conflict-related theta and movement-related beta networks, that are separated spatially, spectrally, and temporally, but which interact dynamically to mediate motor performance, highlighting complex parallel yet interacting networks regulating movement.
AB - While medial frontal cortex (MFC) and subthalamic nucleus (STN) have been implicated in conflict monitoring and action inhibition, respectively, an integrated understanding of the spatiotemporal and spectral interaction of these nodes and how they interact with motor cortex (M1) to definitively modify motor behavior during conflict is lacking. We recorded neural signals intracranially across presupplementary motor area (preSMA), M1, STN, and globus pallidus internus (GPi), during a flanker task in 20 patients undergoing deep brain stimulation implantation surgery for Parkinson disease or dystonia. Conflict is associated with sequential and causal increases in local theta power from preSMA to STN to M1 with movement delays directly correlated with increased STN theta power, indicating preSMA is the MFC locus that monitors conflict and signals STN to implement a ‘break.’ Transmission of theta from STN-to-M1 subsequently results in a transient increase in M1-to-GPi beta flow immediately prior to movement, modulating the motor network to actuate the conflict-related action inhibition (i.e., delayed response). Action regulation during conflict relies on two distinct circuits, the conflict-related theta and movement-related beta networks, that are separated spatially, spectrally, and temporally, but which interact dynamically to mediate motor performance, highlighting complex parallel yet interacting networks regulating movement.
KW - Action regulation
KW - Basal-ganglia cortical network
KW - Conflict processing
KW - Conflict-related theta network
KW - Intracranial neural recordings
KW - Movement-related beta network
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UR - http://www.scopus.com/inward/citedby.url?scp=85190512587&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2024.102613
DO - 10.1016/j.pneurobio.2024.102613
M3 - Article
C2 - 38631480
AN - SCOPUS:85190512587
SN - 0301-0082
VL - 236
JO - Progress in Neurobiology
JF - Progress in Neurobiology
M1 - 102613
ER -