Abstract
Objectives To assess the value of dynamic contrast-enhanced (DCE) combined with T2-weighted (T2W) endorectal coil (ERC) magnetic resonance imaging (MRI) at 3 T for determining extracapsular extension (ECE) of prostate cancer. Methods In this IRB-approved study, ERC 3-T MRI of the prostate was performed in 108 patients before radical prostatectomy. T2W fast spin-echo and DCE 3D gradient echo images were acquired. The interpretations of readers with varied experience were analysed. MRI-based staging results were compared with radical prostatectomy histology. Descriptive statistics were generated for prediction of ECE and staging accuracies were determined by the area under the receiver-operating characteristic curve. Results The overall sensitivity, specificity, positive predictive value and negative predictive value for ECE were 75 %, 92 %, 79 % and 91 %, respectively. Diagnostic accuracy for staging was 86 %, 80 % and 91 % for all readers, experienced and less experienced readers, respectively. Conclusions ERC 3-T MRI of the prostate combining DCE and T2W imaging is an accurate pretherapeutic staging tool for assessment of ECE in clinical practice across varying levels of reader experience.
Original language | English (US) |
---|---|
Pages (from-to) | 2201-2210 |
Number of pages | 10 |
Journal | European Radiology |
Volume | 22 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2012 |
Keywords
- Cancer staging
- Clinical interpretation
- Learning curve
- Magnetic resonance imaging
- Prostate cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging