Predicting Sequence Features, Function, and Structure of Proteins Using MESSA

Archana S. Bhat, Nick V. Grishin

Research output: Contribution to journalArticlepeer-review


MEta-Server for protein Sequence Analysis (MESSA) is a tool that facilitates widespread protein sequence analysis by gathering structural (local sequence properties and three-dimensional structure) and functional (annotations from SWISS-PROT, Gene Ontology terms, and enzyme classification) predictions for a query protein of interest. MESSA uses multiple well-established tools to offer consensus-based predictions on important aspects of protein sequence analysis. Being freely available for noncommercial users and with a user-friendly interface, MESSA serves as an umbrella platform that overcomes the absence of a comprehensive tool for predictive protein analysis. This article reveals how to access MESSA via the Web and shows how to input a protein sequence to analyze using the MESSA web server. It also includes a detailed explanation of the output from MESSA to aid in better interpretation of results.

Original languageEnglish (US)
Article numbere84
JournalCurrent Protocols in Bioinformatics
Issue number1
StatePublished - Sep 2019


  • predictions
  • protein sequence
  • structure and function

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry


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